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FOXO4, p53, and apoptosis appear together because the literature has examined how FOXO4-p53 interaction models relate to senescent cell viability and programmed cell death research [3], [4], [17]

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The clinical trial most often cited is Leyden and colleagues' 2002 randomized 12-week trial of a GHK-Cu facial and eye cream in 71 women with photoaged skin [4]